Jianbo Wan

 

  Jianbo Wan  萬建波
Associate Professor

Academic Qualifications

  • BSc., Wuhan University, Wuhan, China
  • MSc., China Pharmaceutical University, Nanjing China
  • MSc., University of Macau, Macao, China
  • PhD., University of Macau, Macao, China
  • Postdoctoral training, Massachusetts General Hospital and Harvard Medical School, Boston, USA

Teaching

GEST022 Nutrition and Food Safety
CMED717 Development of New Drugs and Health Products
CMED724 Application of Pharmacokinetics and Metabonomics in Drug Development
CMED806 Functional Food Product Development in Chinese Medicine

 

Research

Research Interests

  • Quality Evaluation of Chinese Medicines;
  • Metabonomic Study on Chinese Medicines and Metabolic Diseases;
  • Pharmacological Study on Chinese Medicines for the Prevention of Metabolic Diseases, including Fatty liver and Atherosclerosis
  • Chemical-induced Liver Injury

Selected Publications

Book & Chapter

  1. Wan JB, Wang YT, Li SP. Panax notoginseng (Sanqi 三七). In Chinese herbs: Pharmacological Activities and Quality Control. Shaoping Li, Ed. Nova Science Publishers, Inc.: New York, 2008: 179-203. (ISBN: 978-1-60456-823-3)
  2. Wan JB, Chen Y, Li Ping, Huang WH, Zhang QW. Saponins from Panax Species: Chemistry, Isolation and Analysis. In: Saponins: Properties, Applications and Health Benefits. Rani Koh and Isaac Tay ed., Nova Science Publishers, Inc. New York, 2012: 51-98. (ISBN: 978-1-62100-942-9)
  3. Zhang XJ, Su HX, Wang YT, Wan JB*,. Therapeutic Potential of Ginsenosides in Management of Atherosclerosis. In: Phytotherapies: Efficacy, Safety and Regulation. Iqbal Ramzan ed., Wiley, Inc. 2015: 236-2322258. (ISBN: 978-1-118-26806-3)

Journals (as first author or corresponding author)

  1. Feng R, Wang Y, Liu C, Yan C, Zhang H, Su H, Kang JX, Shang CZ, Wan JB*. Acetaminophen-induced Liver Injury is Attenuated in Transgenic fat-1 Mice Endogenously Synthesizing Long-chain n-3 Fatty Acids. Pharmacol. 2018, 154, 75-88. (IF 4.6)
  2. Zhang M, Wang Y, Zhang Q, Wang C, Zhang D, Wan JB*, Yan C*. UPLC/Q-TOF-MS-based metabolomics study of the anti-osteoporosis effects of Achyranthes bidentata polysaccharides in ovariectomized rats. Int J Biol Macromol. 2018; 112: 433-441. (IF 3.6)
  3. Ma LJ, Liu F, Zhong ZF, Wan JB*,Comparative Study on Chemical Components and Anti-inflammatory Effects of Panax notoginseng Flower Extracted by Water and Methanol., J Sep Sci. 2017, 40: 4730-4739 (IF 2.56)
  4. Feng RB, Wang Y, He C, Yang Y, Wan JB*, Gallic acid, a natural polyphenol, protects against tert-butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response. Food Chem Toxicol. 2017 Oct 21. pii: S0278-6915(17)30631-2 (IF 3.78)
  5. Wang Y, Feng R, Wang R, Yang F, Li P, Wan JB*, Enhanced MS/MS coverage for metabolite identification in LC-MS-based untargeted metabolomics by target-directed data dependent acquisition with time-staggered precursor ion list. Anal Chim Acta. 2017; 992:67-75 (IF 4.95)
  6. Wang M, Zhang XJ, Feng R, Jiang Y, Zhang DY, He C, Li P, Wan JB*. Hepatoprotective properties of Penthorum chinense Pursh against carbon tetrachloride-induced acute liver injury in mice. Chin Med. 2017 Oct 30;12:32 (IF 1.4)
  7. Wang M, Zhang X, Ma LJ, Feng RB, Yan C, Su H, He C, Kang JX, Liu B, Wan JB*, Omega-3 polyunsaturated fatty acids ameliorate ethanol-induced adipose hyperlipolysis: A mechanism for hepatoprotective effect against alcoholic liver disease. Biochim Biophys Acta. 2017 Aug 25;1863(12):3190-3201 (IF 5.48)
  8. Fang Liu, Ni Ma, Fang-Bo Xia, Peng Li, Chengwei He, Zhenqiang Wu, Wan JB*, Preparative separation of minor saponins from Panax notoginseng leaves using biotransformation, macroporous resins and preparative high-performance liquid chromatography. J. Ginseng Res. In press (IF 4.1)
  9. Liu F, Ma N, He C, Hu Y, Li P, Chen M, Su H, Wan JB*. Qualitative and quantitative analysis of the saponins in Panax notoginseng leaves using ultra-performance liquid chromatography coupled with time-of-flight tandem mass spectrometry and high performance liquid chromatography coupled with UV detector. J. Ginseng Res, accepted. (IF 4.1)
  10. Zhang C, Li C, Chen S, Li Z, Ma L, Jia X, Wang K, Bao J, Liang Y, Chen M, Li P, Su H, Lee SM, Liu K, Wan JB*, He C. Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Sci Rep. 2017 Jan 23;7:41082. doi: 10.1038/ srep41082. (IF 4.26)
  11. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB*, Phytochemical and phytopharmacological review of Perilla frutescens (Labiatae), a traditional edible-medicinal herb in China. Food Chem. Toxicol. 2016, pii: S0278-6915(16)30439-2. (IF 3.78)
  12. Feng RB, Wang M, Yan C, Li P, Chen M, He CW, Wan JB*. Endogenous n-3 fatty acids alleviates carbon tetrachloride-induced acute liver injury in fat-1 transgenic mice. Med. Cell. Longev. 2016; 2016:796294. (IF 4.59)
  13. Bao J, Liu F, Zhang C, Wang K, Jia X, Wang X, Chen M, Li P, Su H, Wang Y, Wan JB*, He C*. Anti-melanoma activity of Forsythiae Fructus aqueous extract in mice involves regulation of glycerophospholipid metabolisms by UPLC/Q-TOF MS-based metabolomics study. Sci Rep. 2016 Dec 19;6: 39415. (IF 4.26)
  14. Chen XJ, Zhang XJ, Shui YM, Wan JB*, Gao JL. Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites. Based Complement. Alternat. Med. 2016; 2016: 5738694. (IF 1.74)
  15. Wang Y, Liu F, Li P, He C, Wang R, Su H, Wan JB*. An improved pseudotargeted metabolomics approach using multiple ion monitoring with time-staggered ion lists based on ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Anal Chim Acta. 2016; 927:82-8 (IF 4.95)
  16. Wang M, Zhang XJ, Feng K, He C, Li P, Hu YJ, Su H, Wan JB*. Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice. Rep. 2016; 6:26826 (IF 4.26)
  17. Wang M, Zhang XJ, Yan CY, He C, Li P, Chen M, Su H, Wan JB*. Preventive effect of α-linolenic acid-rich flaxseed oil against ethanol-induced liver injury is associated with ameliorating gut-derived endotoxin-mediated inflammation in mice. Funct. Foods, 2016, 23: 532-541. (IF 3.14)
  18. Wang YZhou SWang MLiu SHu YHe CLi PWan JB*. UHPLC/Q-TOFMS- based metabolomics for the characterization of cold and hot properties of Chinese materia medica. Ethnopharmacol.2016, 79: 234-242. (IF 2.98)
  19. Chen XJ, Qiu JF, Wang YT, Wan JB*. Discrimination of Three Panax Species Based on Differences in Volatile Organic Compounds Using a Static Headspace GC-MS-Based Metabolomics Approach. J. Chin. Med.2016, 24:1-14. (IF 3.2)
  20. Chen YXZhang XJHuang JZhou SJLiu FJiang LLChen MWan JB*Yang DZ. UHPLC/Q-TOFMS-based plasma metabolomics of polycystic ovary syndrome patients with and without insulin resistance. Pharm. Biomed. Anal.2016, 20; 121:141-50. (IF 3.26)
  21. Wang M, Zhang XJ, Liu F, Hu Y, He C, Li P, Su H, Wan JB*. Saponins isolated from the leaves of Panax notoginseng protect against alcoholic liver injury via inhibiting ethanol-induced oxidative stress and gut-derived endotoxin-mediated inflammation. Funct. Foods, 2015, 214-224 (IF 3.14)
  22. Qiu JF, Zhang KL, Zhang XJ, Hu YJ, Li P, Shang CZ, Wan JB*, Abnormalities in Plasma Phospholipid Fatty Acid Profiles of Patients with Hepatocellular Carcinoma, Lipids, 2015; 50(10): 977-85 (IF 1.93)
  23. Wang Y, Liu S, Hu YJ, Li P, Wan JB*. Current state-of-the-art of mass spectrometry-based metabolomics studies-A review focusing on wide coverage, high throughput and easy identification. RSC Advances, 2015, 5, 78728-78737 (IF 3.10)
  24. Liu F, Ding RB, Hu YJ, Su H, Wan JB*, UPLC/Q-TOFMS-based metabolomics studies on the protective effect of Panax notoginseng saponins on alcoholic liver injury. J. Chin. Med., 2015 Jul 1:1-20 (IF 3.22)
  25. Liu F, Bai X, Yang FQ, Zhang XJ, Hu Y, Li P, Wan JB*. Discrimination of Curcumae Radix derived from four species using UHPLC/Q-TOFMS-based metabolomics approach. Med., 2016 ;11: 21(IF 1.45)
  26. Zhang XJ, He C, Tian K, Li P, Su H, Wan JB*, Ginsenoside Rb1 attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the JNK and p38 signaling pathways. Pharmacol.2015, 73: 86-95 (IF 3.71)
  27. Zhang XJ, He C, Li P, Su H, Wan JB*, Ginsenoside Rg1, a potential JNK inhibitor, protects against ischemia/reperfusion-induced liver damage. Funct. Foods, 2015, 15, 580–592 (IF 3.14)
  28. Cao YW, Jiang Y, Zhang DY, Zhang XJ, Hu YJ, Li P, Su H, Wan JB*, Hepatoprotective effect of aqueous extracts of Penthorum chinense Pursh against acute alcohol-induced liver injury is associated with ameliorating hepatic steatosis and reducing oxidative stress. Food Funct., 2015 6(5):1510-7 (IF 3.25)
  29. Ding RB, Tian K, Cao YW, Bao JL, Wang M, He C, Hu Y, Su H, Wan JB*. Protective Effect of Panax notoginseng Saponins on Acute Ethanol-induced Liver Injury is Associated with Ameliorating Hepatic Lipid Accumulation and Reducing Ethanol-mediated Oxidative Stress. J. Agric. Food. Chem. 2015 63(9):2413-22. (IF 3.15)
  30. Cao Y, Jiang Y, Zhang D, Wang M, Chen W, Su H, Wang Y, Wan JB*. Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice. Ethnopharmacol. 2015,161:92-98. (IF 2.98)
  31. Xu FX, Yuan C, Wan JB*, Yan R, Hu H, Li SP, Zhang QW. A novel strategy for rapid quantification of 20(S)-protopanaxatriol and 20(S)-protopanaxadiol saponins in Panax notoginseng, P. ginseng and P. quinquefolium. Nat Prod Res. 2014, 11:1-7 (IF 1.83)
  32. Zhang XJ, Huang LL, Su H, Chen YX, Huang J, He C, Li P, Yang DZ, Wan JB*, Characterizing plasma phospholipid fatty acid profiles of polycystic ovary syndrome patients with and without insulin resistance using GC-MS and chemometrics approach. J. Pharm. Biomed. Anal. 2014, 95C:85-92 (IF 3.22)
  33. Zhang XJ, Su H, He CW, Wang YT, Yang FQ, Wan JB*. Discrimination of Pterocephalus hookeri collected at flowering and non-flowering stages using GC-MS-based fatty acid profiling. Anal. Methods, 2014,6, 2141-2149 (IF 1.9)
  34. Zhang XJ, Qiu JF, Guo LP, Wang Y, Li P, Yang FQ, Su H, Wan JB*. Discrimination of multi-origin Chinese herbal medicines using gas chromatography-mass spectrometry-based Fatty Acid profiling. Molecules. 2013 Dec 11;18(12):15329-43 (IF 2.86)
  35. Wan JB*, Bai X, Cai XJ, Rao Y; Wang, YS, Wang YT. Chemical differentiation of Da-Cheng-Qi-Tang, a Chinese medicine formula, prepared by traditional and modern decoction methods using UPLC/Q-TOFMS-based metabolomics approach. J Pharm Biomed Anal, 2013, 83C:34-42 (IF 3.22)
  36. Huang LL, Wan JB*, Wang B, He CW, Ma H, Li TW, Kang JX*. Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. Prostaglandins Leukot Essent Fatty Acids. 2013; 88(5):347-53 (IF 2.65)
  37. Zhang XJ, Huang LL, Cai XJ, Li P, Wang YT, Wan JB*. Fatty acid variability in three medicinal herbs of Panax species. Chem Cent J. 2013 Jan 21;7(1):12. (IF 2.44)
  38. Ding RB, Tian K, He CW, Jiang Y, Wang YT, Wan JB*. Herbal medicines for the prevention of alcoholic liver diseases: a review. J Ethnopharmacol. 2012, 144(3):457-65. (IF 2.98)
  39. Wan JB, Li P, Yang RL, Zhang QW, Wang YT. Separation and purification of 5 saponins from Panax notoginseng by preparative high-performance liquid chromatography. J Liq Chromatogr RT. 2013, 36:406–417. (IF 0.70)
  40. Wan JB, Zhang QW, Hong SJ, Li P, Li SP, Wang YT. Chemical investigation of saponins in different parts of Panax notoginseng by pressurized liquid extraction and liquid chromatography-electrospray ionization- tandem mass spectrometry. Molecules. 2012,17(5):5836-53 (IF 2.86)
  41. Wan JB, LL Huang, Rong R, Tan R, J Wang, JX Kang. Endogenously Decreasing Tissue n-6/n-3 Fatty Acid Ratio Reduces Atherosclerotic Lesions in Apolipoprotein E-Deficient Mice by Inhibiting Systemic and Vascular Inflammation. Arterioscler. Thromb. Vasc. Biol. 2010, 30: 2487-2494. (IF 6.6)
  42. Comment in: Deckelbaum RJ. n-6 and n-3 Fatty Acids and Atherosclerosis: Ratios or Amounts? Arterioscler Thromb Vasc Biol. 2010; 30: 2325-2326.
  43. Wan JB, Lee SM, Wang JD, Wang N, He CW, Wang YT, Kang JX. Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion. J. Agric. Food. Chem. 2009, 57: 6692-6697. (IF 3.15)
  44. Wan JB, QW Zhang, SJ Hong, J Guan, WC Ye, SP Li, MY Lee, YT Wang. 5,6-Didehydrogin senosides from the Roots of Panax notoginseng. Molecules. 2010, 15: 8169-8176. (IF 2.86)
  45. Wan JB, QW Zhang, WC Ye, YT Wang, Quantification and separation of protopanaxatriol and protopanaxadiol type saponins from Panax notoginseng with macroporous resins. Sep. Pur. Tech. 2008, 60: 198-205. (IF 3.36)
  46. Wan JB, YT Wang, JM Chen, SP Li. Chemical characteristics for three medicinal plants from Panax genus using pressurized liquid extraction and HPLC-ELSD. J. Sep. Sci. 2007, 30: 825-832. (IF 2.56)
  47. Wan JB, CM Lai, SP Li, MY Lee, LY Kong, YT Wang. Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction. J Pharm Biomed Anal. 2006, 41: 274-279. (IF 3.26)
  48. Wan JB, SP Li, YT Wang. Chemical characteristics of different parts from Panax notoginseng by HPLC-ELSD. J Pharm Biomed Anal. 2006, 41: 1596-1601. (IF 3.26)
  49. Wan JB, P Li, SP Li, YT Wang, TX Dong, Karl WK Tsim. Simultaneous determination of 11 saponins in Panax notoginseng using HPLC-ELSD and pressurized liquid extraction. J. Sep. Sci. 2006, 29: 2190-2196. (IF 2.56)
  50. Wan JB, C Xu, SP Li, LY Kong, YT Wang. Studies on the pressurized solvent extraction of isoflavonoids from Pueraria Lobata. Chin. Anal. Chem. 2005, 33: 1435~1438. (IF 0.80)
  51. Wan JB, SP Li, JR Jian, LY Kong, YT Wang. Analysis of Saponins from Panax notoginseng Using Pressurized Solvent Extraction Coupled with High Performance Thin Layer Chromatography. Chin J Nat Med. 2004, 2: 215-218 (IF 1.66)


Qualification

  • Executive Council Member, Specialty Committee of Li Shizhen Medicine, World Federation of Chinese Medicine Societies;
  • Executive Council Member, Specialty Committee of Chinese Medicine Healthcare Products, World Federation of Chinese Medicine Societies
  • Executive Council Member. The Professional Civil Sercants Association of Macao
  • President of a Council, International Association of Quality Research in Chinese Medicine

Contact Details

Institute of Chinese Medical Sciences
University of Macau
Macao, China
Room: 6034, N22
Telephone: (853) 8822-4680
Fax: (853) 28841358
E-mail: jbwan@umac.mo